Christina Applegate Hospitalized Over 30 Times in Her Fight Against MS

Christina Applegate is opening up about the grueling challenges of living with multiple sclerosis (MS), and her revelations are nothing short of heartbreaking.

Speaking on her podcast "MeSsy", which she co-hosts with actress Jamie-Lynn Sigler, Applegate shared that she’s been hospitalized "upwards of 30 times" in the last three years since her diagnosis. The 53-year-old actress painted a vivid picture of her struggles, citing symptoms like severe vomiting, diarrhea, and pain that have led to countless medical tests and CT scans. She quipped with raw honesty, "That is unimaginable, OK?"

Applegate also discussed one of the lesser-known ways MS affects her body: the slowing of organ functions. She described a particularly distressing symptom where bouts of vomiting and bowel issues seem to arrive hand-in-hand. Though her neurologist doesn’t believe this specific symptom is directly tied to MS, Applegate is convinced there’s a connection. "I’m not a doctor," she clarified, "but I’m just saying, think about that, OK? Because it f---ing sucks, and it’s scary." That’s putting it lightly.

In a moment of dark humor, she offered a practical tip for others dealing with similar challenges: "Always have a little trash can next to your toilet. Because you can do both without it being messy." That’s life advice no one imagines needing, but here we are.

Applegate first revealed her MS diagnosis in 2021, taking to social media with a message that mixed vulnerability and determination. "It’s been a strange journey," she wrote, adding that support from others with the condition has been a lifeline. "As one of my friends that has MS said, 'We wake up and take the indicated action.' And that's what I do."

However, the actress hasn’t shied away from addressing the emotional toll of her condition. Last year, she openly discussed battling "real depression" that has left her feeling trapped in darkness. "I don’t enjoy living," she admitted, a brutally candid statement that underscores the mental health struggles intertwined with chronic illness.

Despite everything, Applegate continues to share her journey with unflinching honesty and even a touch of humor. It’s a testament to her resilience, though it’s impossible not to wish she didn’t have to be this strong in the first place.