Jim Gaffigan Drops 50 Pounds with Mounjaro, Joins Celebrity Weight-Loss Trend

Comedian Jim Gaffigan, the self-proclaimed "Skinny" funnyman, has dropped a whopping 50 pounds, and he’s not shy about spilling the beans on how he did it. The 58-year-old credits Mounjaro, an injectable drug primarily used for type 2 diabetes, for his dramatic transformation. "I did appetite suppressants, so it's not like I can even take any pride in it," Gaffigan quipped on a recent TV appearance, adding with his signature humor, "I was brave enough to stick a needle in my stomach."

Once tipping the scales at 270 pounds, Gaffigan now revels in the perks of his slimmer frame. "My knees don’t hurt standing up, and I’m less exhausted," he shared, noting the health benefits go beyond just looking good. "I feel better, and I’ll probably live longer," he said, though he admitted his love for food made him skeptical of Mounjaro at first. "I thought my true joy of eating would overpower anything," he confessed, but the drug proved him wrong.

Gaffigan isn’t alone in singing Mounjaro’s praises. Fellow comedian Rosie O’Donnell, 63, recently stunned fans with her own slimmed-down look, sharing a photo on social media captioned with hashtags like #mounjaro and #weightloss. Amy Schumer also jumped on the bandwagon, raving about fuller hair, better skin, and more energy—plus a cheeky nod to an improved love life. Unlike her rough experience with Ozempic, Schumer called Mounjaro a game-changer. "I’m having a really good experience with it," she said in an Instagram video.

While Gaffigan downplays his achievement, his openness about using Mounjaro sparks a broader conversation about weight-loss medications in Hollywood and beyond. For now, he’s enjoying the lighter side of life—literally and figuratively.