Rob Lowe Hilariously Mistaken for John Stamos on Hollywood Tour: Tells Guide to Step Up His Game

Rob Lowe found himself in the middle of a classic Hollywood mix-up when a tour guide introduced him to a bus full of tourists as none other than John Stamos. The actor, known for his roles in "The Outsiders" and "St. Elmo’s Fire," was quick to catch the case of mistaken identity—and handled it like a true comedic pro.

In a video making the rounds on social media, Lowe’s disbelief was clear as he reacted with a colorful, "What the f---," after hearing the tour guide's bold declaration. The guide, trying to save face, insisted, "He looks like him, you know," which only added to the laughter bubbling up from the bus.

Lowe couldn’t resist joining in, approaching the group with a smile and asking, "Hey guys, am I John Stamos?" The tourists, clearly familiar with their '80s and '90s heartthrobs, responded in unison: "No, Rob Lowe!"

Never one to miss a joke, Lowe called out to the guide, "Dude, you got to get better at your job!" The guide, taking it in stride, admitted, "It’s usually about having fun, you know. I didn’t expect to run into people." Lowe wrapped up his cameo with a wink to the crowd, telling them, "Oh, I see, don’t listen to him." The guide could only laugh and thank Lowe for his "cool energy."

On Instagram, Lowe tagged his son, John Owen Lowe, and wondered aloud if he was being "Punk’d." His son’s response? "The people have spoken." Even other celebrities couldn’t resist chiming in—Kimberly Williams-Paisley joked, "I love you John Stamos!" and Holly Robinson Peete quipped that the tour guide "needs to be fired immediately."

Turns out, this isn’t the first time Lowe’s been caught in the Stamos switcheroo. Just last month, his son posted a black-and-white photo of Stamos instead of Lowe for his dad’s birthday tribute, and even photoshopped Stamos’ face onto a picture from the "Unstable" season two premiere. Lowe shared on "The Drew Barrymore Show" that his son has even swapped in Stamos on the family Christmas cards. As Stamos himself joked in a surprise video message, "I’m tired of explaining that ‘no, I’m not really his dad, I’m a better-looking version of his dad.’"

Mix-ups aside, it’s clear both actors—and their families—are having a blast with the ongoing doppelgänger saga. Honestly, if you can’t laugh at being mistaken for John Stamos, are you even a Hollywood legend?